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IFN-λ signaling promotes dendritic cell infiltration to the uterus during congenital ZIKV infection. Dams from Ifnar1 -/- x Ifnar1 -/- Ifnlr1 -/- or Ifnar1 -/- Ifnlr1 -/- x Ifnar1 -/- crosses were infected at E9 with ZIKV FSS13025 by subcutaneous injection in the footpad. (A) Gravid uteruses were harvested at E15 and analyzed by flow cytometry (4 Ifnar1 -/- dams and 5 Ifnar1 -/- Ifnlr1 -/- dams collected in 4 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in the uterus. (B-C) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in uteruses from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ***, P < 0.001). (D) Placentas were harvested at E15 and analyzed by flow cytometry (38 placentas from 5 Ifnar1 -/- dams and 59 placentas from 8 Ifnar1 -/- Ifnlr1 -/- dams collected in 6 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in placentas. (E-F) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in placentas from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ns, no significant difference). (G) Representative images of implantation sites. Gravid uteruses were harvested <t>at</t> <t>E13.</t> Sections of entire gravid uteruses (2 Ifnar1 -/- dams and 2 Ifnar1 -/- Ifnlr1 -/- dams per group, collected in independent experiments) were probed for <t>Itgax</t> RNA (pink), indicating dendritic cells, and stained with DAPI (blue). Spots were assigned based on the quality of the Itgax signal (white). Scale bars in zoomed images are 80µm.
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IFN-λ signaling promotes dendritic cell infiltration to the uterus during congenital ZIKV infection. Dams from Ifnar1 -/- x Ifnar1 -/- Ifnlr1 -/- or Ifnar1 -/- Ifnlr1 -/- x Ifnar1 -/- crosses were infected at E9 with ZIKV FSS13025 by subcutaneous injection in the footpad. (A) Gravid uteruses were harvested at E15 and analyzed by flow cytometry (4 Ifnar1 -/- dams and 5 Ifnar1 -/- Ifnlr1 -/- dams collected in 4 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in the uterus. (B-C) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in uteruses from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ***, P < 0.001). (D) Placentas were harvested at E15 and analyzed by flow cytometry (38 placentas from 5 Ifnar1 -/- dams and 59 placentas from 8 Ifnar1 -/- Ifnlr1 -/- dams collected in 6 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in placentas. (E-F) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in placentas from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ns, no significant difference). (G) Representative images of implantation sites. Gravid uteruses were harvested <t>at</t> <t>E13.</t> Sections of entire gravid uteruses (2 Ifnar1 -/- dams and 2 Ifnar1 -/- Ifnlr1 -/- dams per group, collected in independent experiments) were probed for <t>Itgax</t> RNA (pink), indicating dendritic cells, and stained with DAPI (blue). Spots were assigned based on the quality of the Itgax signal (white). Scale bars in zoomed images are 80µm.
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IFN-λ signaling promotes dendritic cell infiltration to the uterus during congenital ZIKV infection. Dams from Ifnar1 -/- x Ifnar1 -/- Ifnlr1 -/- or Ifnar1 -/- Ifnlr1 -/- x Ifnar1 -/- crosses were infected at E9 with ZIKV FSS13025 by subcutaneous injection in the footpad. (A) Gravid uteruses were harvested at E15 and analyzed by flow cytometry (4 Ifnar1 -/- dams and 5 Ifnar1 -/- Ifnlr1 -/- dams collected in 4 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in the uterus. (B-C) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in uteruses from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ***, P < 0.001). (D) Placentas were harvested at E15 and analyzed by flow cytometry (38 placentas from 5 Ifnar1 -/- dams and 59 placentas from 8 Ifnar1 -/- Ifnlr1 -/- dams collected in 6 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in placentas. (E-F) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in placentas from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ns, no significant difference). (G) Representative images of implantation sites. Gravid uteruses were harvested <t>at</t> <t>E13.</t> Sections of entire gravid uteruses (2 Ifnar1 -/- dams and 2 Ifnar1 -/- Ifnlr1 -/- dams per group, collected in independent experiments) were probed for <t>Itgax</t> RNA (pink), indicating dendritic cells, and stained with DAPI (blue). Spots were assigned based on the quality of the Itgax signal (white). Scale bars in zoomed images are 80µm.
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IFN-λ signaling promotes dendritic cell infiltration to the uterus during congenital ZIKV infection. Dams from Ifnar1 -/- x Ifnar1 -/- Ifnlr1 -/- or Ifnar1 -/- Ifnlr1 -/- x Ifnar1 -/- crosses were infected at E9 with ZIKV FSS13025 by subcutaneous injection in the footpad. (A) Gravid uteruses were harvested at E15 and analyzed by flow cytometry (4 Ifnar1 -/- dams and 5 Ifnar1 -/- Ifnlr1 -/- dams collected in 4 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in the uterus. (B-C) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in uteruses from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ***, P < 0.001). (D) Placentas were harvested at E15 and analyzed by flow cytometry (38 placentas from 5 Ifnar1 -/- dams and 59 placentas from 8 Ifnar1 -/- Ifnlr1 -/- dams collected in 6 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in placentas. (E-F) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in placentas from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ns, no significant difference). (G) Representative images of implantation sites. Gravid uteruses were harvested <t>at</t> <t>E13.</t> Sections of entire gravid uteruses (2 Ifnar1 -/- dams and 2 Ifnar1 -/- Ifnlr1 -/- dams per group, collected in independent experiments) were probed for <t>Itgax</t> RNA (pink), indicating dendritic cells, and stained with DAPI (blue). Spots were assigned based on the quality of the Itgax signal (white). Scale bars in zoomed images are 80µm.
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IFN-λ signaling promotes dendritic cell infiltration to the uterus during congenital ZIKV infection. Dams from Ifnar1 -/- x Ifnar1 -/- Ifnlr1 -/- or Ifnar1 -/- Ifnlr1 -/- x Ifnar1 -/- crosses were infected at E9 with ZIKV FSS13025 by subcutaneous injection in the footpad. (A) Gravid uteruses were harvested at E15 and analyzed by flow cytometry (4 Ifnar1 -/- dams and 5 Ifnar1 -/- Ifnlr1 -/- dams collected in 4 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in the uterus. (B-C) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in uteruses from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ***, P < 0.001). (D) Placentas were harvested at E15 and analyzed by flow cytometry (38 placentas from 5 Ifnar1 -/- dams and 59 placentas from 8 Ifnar1 -/- Ifnlr1 -/- dams collected in 6 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in placentas. (E-F) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in placentas from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ns, no significant difference). (G) Representative images of implantation sites. Gravid uteruses were harvested at E13. Sections of entire gravid uteruses (2 Ifnar1 -/- dams and 2 Ifnar1 -/- Ifnlr1 -/- dams per group, collected in independent experiments) were probed for Itgax RNA (pink), indicating dendritic cells, and stained with DAPI (blue). Spots were assigned based on the quality of the Itgax signal (white). Scale bars in zoomed images are 80µm.

Journal: bioRxiv

Article Title: Interferon lambda signaling to maternal dendritic cells protects against congenital Zika virus infection

doi: 10.64898/2026.01.25.701624

Figure Lengend Snippet: IFN-λ signaling promotes dendritic cell infiltration to the uterus during congenital ZIKV infection. Dams from Ifnar1 -/- x Ifnar1 -/- Ifnlr1 -/- or Ifnar1 -/- Ifnlr1 -/- x Ifnar1 -/- crosses were infected at E9 with ZIKV FSS13025 by subcutaneous injection in the footpad. (A) Gravid uteruses were harvested at E15 and analyzed by flow cytometry (4 Ifnar1 -/- dams and 5 Ifnar1 -/- Ifnlr1 -/- dams collected in 4 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in the uterus. (B-C) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in uteruses from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ***, P < 0.001). (D) Placentas were harvested at E15 and analyzed by flow cytometry (38 placentas from 5 Ifnar1 -/- dams and 59 placentas from 8 Ifnar1 -/- Ifnlr1 -/- dams collected in 6 independent experiments). Representative flow cytometry plots of leukocytes stained for CD11c in placentas. (E-F) Frequency and number of dendritic cells (CD11c hi out of CD45 + ) in placentas from Ifnar1 -/- and Ifnar1 -/- Ifnlr1 -/- dams. Groups were compared by unpaired t -test (****, P < 0.0001; ns, no significant difference). (G) Representative images of implantation sites. Gravid uteruses were harvested at E13. Sections of entire gravid uteruses (2 Ifnar1 -/- dams and 2 Ifnar1 -/- Ifnlr1 -/- dams per group, collected in independent experiments) were probed for Itgax RNA (pink), indicating dendritic cells, and stained with DAPI (blue). Spots were assigned based on the quality of the Itgax signal (white). Scale bars in zoomed images are 80µm.

Article Snippet: We harvested tissues at E13, probed for Itgax (CD11c), and assigned Itgax+ spots in Imaris ( ).

Techniques: Infection, Injection, Flow Cytometry, Staining